Integrated Treatment during the Intravitreal Melphalan Era: Concurrent Intravitreal Melphalan and Systemic Chemoreduction
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چکیده
منابع مشابه
Intravitreal and Subconjunctival Melphalan for Retinoblastoma in Transgenic Mice
Purpose. To measure the chemotherapeutic effects of focal melphalan (intravitreal and subconjunctival) on tumor burden, hypoxia, and vasculature in LHBETATAG murine retinoblastoma model. Methods. LHBETATAG transgenic mice were treated with a single 1 mcg intravitreal injection of melphalan, 100 mcg subconjunctival injection, or semiweekly 10 mcg subconjunctival injections for 3 weeks. At 1 or 3...
متن کاملStability of melphalan solution for intravitreal injection for retinoblastoma.
Stability ofMelphalan Solution for Intravitreal Injection for Retinoblastoma Intravitreal injections for the treatmentof retinoblastomahave been gaining relevance among ophthalmologists, supported by reports on outcome and improvement of the administration technique.1 Currently, doses up to 30 μg per injection are used according to an extensively described technique for intravitreal injection t...
متن کاملIntravitreal melphalan for refractory or recurrent vitreous seeding from retinoblastoma.
OBJECTIVE To evaluate the efficacy and complications of intravitreal chemotherapy for viable vitreous seeding from retinoblastoma. METHODS Intravitreal injection of melphalan (8-50 μg in 0.05 mL) followed by injection site cryotherapy. RESULTS Among 12 treated cases, success with control of vitreous seeds was achieved in 10 of 12 cases at immediate follow-up (0-3 months), 8 of 10 cases at s...
متن کاملIntravitreal Melphalan for Vitreous Seeds: Initial Experience in China
Purpose. To evaluate the efficacy of intravitreal melphalan for vitreous seeds from retinoblastoma in Chinese patients. Methods. This is a retrospective review of 17 consecutive Chinese patients (19 eyes) with viable vitreous seeds from retinoblastoma. The patients received multiple intravitreal injections of 20 ug melphalan. Results. The International Classification of Retinoblastoma groups we...
متن کاملCombined intravitreal melphalan and topotecan for refractory or recurrent vitreous seeding from retinoblastoma.
IMPORTANCE Demonstrating the usefulness and complications of multiagent intravitreal chemotherapy is necessary for successful treatment in patients with recalcitrant vitreous seeding of retinoblastoma. OBJECTIVE To determine the efficacy and complications of combined intravitreal chemotherapy (melphalan hydrochloride and topotecan hydrochloride) for viable vitreous seeding from retinoblastoma...
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ژورنال
عنوان ژورنال: Ocular Oncology and Pathology
سال: 2018
ISSN: 2296-4681,2296-4657
DOI: 10.1159/000486098